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  • Title: Presence of 3-deoxyglucosone, a potent protein crosslinking intermediate of Maillard reaction, in diabetic serum.
    Author: Niwa T, Takeda N, Yoshizumi H, Tatematsu A, Ohara M, Tomiyama S, Niimura K.
    Journal: Biochem Biophys Res Commun; 1993 Oct 29; 196(2):837-43. PubMed ID: 8240359.
    Abstract:
    3-Deoxyglucosone, a potent protein crosslinking intermediate of the Maillard reaction, was first detected in diabetic serum using gas chromatography/mass spectrometry. Serum concentration of 3-deoxyglucosone was elevated in diabetic patients as compared with healthy subjects. More notably, diabetic patients with nephropathy showed higher serum concentration of 3-deoxyglucosone than those without nephropathy. The increased serum concentration of 3-deoxyglucosone in the diabetic patients suggests that 3-deoxyglucosone may be responsible for the development of diabetic complications such as diabetic nephropathy by promoting the formation of advanced glycation end products.
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