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  • Title: Synthesis and evaluation of the antidepressant activity of the enantiomers of bupropion.
    Author: Musso DL, Mehta NB, Soroko FE, Ferris RM, Hollingsworth EB, Kenney BT.
    Journal: Chirality; 1993; 5(7):495-500. PubMed ID: 8240925.
    Abstract:
    The synthesis of the enantiomers of bupropion, (rac)-2-tert-butylamino-3'-chloropropiophenone 1 (Wellbutrin) is described. The enantiomers were compared with the racemate in both the tetrabenazine-induced sedation model and the inhibition of uptake of biogenic amine assay. No significant differences were found in their potencies to reverse tetrabenazine-induced sedation in mice or in their IC50 values as inhibitors of biogenic amine uptake into nerve endings obtained from mouse brain.
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