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  • Title: Comparative studies of sheep immunoglobulins IgG1 and IgG2: amino acid sequence of carboxy-terminal cyanogen bromide fragments from their heavy chains.
    Author: Conde FP, Deverson EV, Milstein CP.
    Journal: Eur J Immunol; 1975 Apr; 5(4):291-3. PubMed ID: 824134.
    Abstract:
    Sheep immunoglobulin IgG1 and immunoglobulin IgG2 heavy chains were treated with cyanogen bromide. The fractions from the C-terminal end of the heavy chains were isolated and purified, and the amino acid sequences gamma1 and gamma2 heavy chains had the identical sequence: Met-His-Glx-Ala-Leu-His-Asx-His-Tyr-Thr-Glx-Lys-Ser-Ile-Ser-Lys-Pro-Pro-Gly. Comparison with the C-terminal peptides of other species, reported in the literature, suggests that the subclasses are the results of recent evolutionary processes. Residues at position 4 from the C-terminus may be phylogenetically related.
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