These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Low-dose heparin inhibits acute graft versus host disease in mice.
    Author: Naparstek E, Slavin S, Weiss L, Sidi H, Ohana M, Reich S, Vlodavsky I, Cohen IR, Naparstek Y.
    Journal: Bone Marrow Transplant; 1993 Sep; 12(3):185-9. PubMed ID: 8241974.
    Abstract:
    We have studied the effect of low-dose heparin on GVHD, marrow engraftment and graft-versus-leukemia (GVL) effects in an experimental murine model. Recipient (C57BL/6 x BALB/c) F1 mice were transplanted with C57BL/6 marrow and/or spleen cells and treated with daily sc injection of 5 micrograms heparin for 30 days. We have shown that heparin in low doses attenuates the severity of acute GVHD and reduces the mortality rate from 69 to 37.5% without abrogating the GVL effect induced by the allograft and without impairing marrow engraftment.
    [Abstract] [Full Text] [Related] [New Search]