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  • Title: [Regulation of glycogenolysis against hormones in isolated rat hepatocytes].
    Author: Chen W.
    Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 1993 Apr; 15(2):123-7. PubMed ID: 8242820.
    Abstract:
    cAMP and Ca(2+)-dependent glycogenolytic pathways are regulated by different hormones involved in the activation of glycogen phosphorylase in isolated rat hepatocytes. Dose-dependent glucagon activation of glycogen phosphorylase and lowering of cAMP levels were obtained by vasopressin and angiotensin treatment. Similar time courses of Ca2+ fluxes and phosphorylase activation were induced by vasopressin, angiotensin and phenylephrine. Heterologous down-regulation of hormones was induced in glycogenolysis in hepatocytes. These results could be of significance in physiology studies in vivo.
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