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  • Title: Hemodynamic effects of a novel hypotensive peptide, human adrenomedullin, in rats.
    Author: Ishiyama Y, Kitamura K, Ichiki Y, Nakamura S, Kida O, Kangawa K, Eto T.
    Journal: Eur J Pharmacol; 1993 Sep 14; 241(2-3):271-3. PubMed ID: 8243562.
    Abstract:
    The hemodynamic effects of human adrenomedullin were investigated in anesthetized Wistar rats. Intravenous administration of adrenomedullin (1.0 nmol/kg) caused a rapid and marked reduction in mean blood pressure associated with a decrease in total peripheral resistance. This reduction in mean blood pressure was closely correlated with the decrease in total peripheral resistance. These findings indicate that human adrenomedullin is a potent vasodilator and may have some role in the regulation of blood pressure.
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