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  • Title: Activation of NF-kappa B by cAMP in human myeloid cells.
    Author: Serkkola E, Hurme M.
    Journal: FEBS Lett; 1993 Nov 22; 334(3):327-30. PubMed ID: 8243641.
    Abstract:
    Nuclear factor kappa B (NF-kappa B) is a DNA-binding regulatory factor that controls the transcription of a number of genes. Various agents are known to activate this factor. We have studied the ability of cAMP to stimulate NF-kappa B activity in human myeloid cells. Electrophoretic mobility assay revealed that structural cAMP analogs and agents elevating intracellular cAMP levels induced NF-kappa B DNA-binding activity. The inducibility was dependent on the maturation stage of myeloid cells. In promyelocytic HL-60 cells cAMP induced higher NF-kappa B activity than in more differential THP-1 cells and in human monocytes. By transfecting HL-60 and THP-1 cells with reporter constructs containing NF-kappa B DNA-binding sites, we observed that cAMP-induced NF-kappa B was transcriptionally active.
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