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  • Title: Rh-immune globulin after amniocentesis for genetic diagnosis.
    Author: Henry G, Wexler P, Robinson A.
    Journal: Obstet Gynecol; 1976 Nov; 48(5):557-9. PubMed ID: 824587.
    Abstract:
    The procedure of amniocentesis during the second trimester of pregnancy for genetic diagnosis creates the potential for Rh sensitization secondary to fetomaternal bleeding. We have advised administration of Rh-immune globulin after such amniocentesis whenever the pregnancy may be Rh-incompatible. Of 56 patients who received Rh-immune globulin there has been only 1 case of Rh sensitization, which occurred in a patient who underwent a second amniocentesis 2 weeks after the first attempt without receiving a second dose of Rh-immune globulin. There have been no developmental problems detected to date which could be ascribed to Rh-immune globulin.
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