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  • Title: Effects of essential fatty acid deficiency and of carbon tetrachloride-induced liver cirrhosis on oral carcinogenesis in the rat.
    Author: Lekholm U, Wallenius K.
    Journal: Odontol Revy; 1976; 27(3):165-80. PubMed ID: 824589.
    Abstract:
    The relative resistance of the oral mucosa to carcinogenic influences was studied in connection with altered fatty acid composition of the oral epithelium in the rat. The water-soluble carcinogen 4-nitrochinoline N-oxide was used. The lipid changes were induced either through essential fatty acid (EFA) deficiency or through carbon tetrachloride-induced liver cirrhosis. Although the strongest initial reaction in the oral mucosa was seen in the EFA-deficient rats, a result considered to be due to increased permeability of the epithelium to the carcinogen, oral carcinoma did not develop earlier in the EFA-deficient group than in normal controls. The liver cirrhotic group developed clinical signs of carcinoma earliest (5.4 months) whereas in EFA-deficient and normal rats carcinoma appeared after an average of 6.0 and 6.5 months, respectively. However, as a previous study (Lekholm 1976) has shown that the fatty acid changes were less pronounced in cirrhotic than in EFA-deficient rats, it would appear that there is no clear correlation between the extent of lipid distrubance and reduced resistance of the oral epithelium to the induction of carcinoma.
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