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  • Title: Morphological and virological studies in six autopsies of children with adenovirus pneumonia.
    Author: Garcia AG, Fonseca ME, de Bonis M, Ramos HI, Ferro ZP, Nascimento JP.
    Journal: Mem Inst Oswaldo Cruz; 1993; 88(1):141-7. PubMed ID: 8246749.
    Abstract:
    Pulmonary lesions compatible with adenovirus infection were detected by gross and microscopic examination of autopsy tissues from children aged from 5 to 34 months. Hepatic lesions indicative of systemic infection were also found in four of the children. The viral etiology was confirmed in three cases by in-situ hybridization, electron-microscopy and immunofluorescence performed in paraffin-embedded tissues, and in one case by cell culture isolation of adenovirus type 2 from nasopharyngeal exudate. Routine testing by methods additional to conventional light microscopy would probably have revealed a larger number of adenovirus infections among the 1,103 autopsy records analyzed in this study.
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