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  • Title: Neuronal-visceral GM1 gangliosidosis in a dog with beta-galactosidase deficiency.
    Author: Read DH, Harrington DD, Keenana TW, Hinsman EJ.
    Journal: Science; 1976 Oct 22; 194(4263):442-5. PubMed ID: 824730.
    Abstract:
    A 9-month-old dog with a history of progressive motor dysfunction was shown to have a deficiency in brain beta-galactosidase activity. The canine disease, like that of children with GM1 gangliosidosis, is characterized by accumulation of GM1 ganglioside in the brain, liver, and spleen, and membranous cytoplasmic bodies in neurons. The dog's pedigree suggests an autosomal recessive pattern of inheritance.
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