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  • Title: [125I]galanin binding sites in the rat frontal lobe are guanine nucleotide-sensitive and display a low regional index of occupancy.
    Author: Lagny-Pourmir I, Crépel F.
    Journal: Neurosci Lett; 1993 Sep 17; 160(1):29-32. PubMed ID: 8247327.
    Abstract:
    As the neuropeptide galanin is possibly involved in spatial learning, we investigated both the precise location and the binding features of the receptors within the rat frontal cortex using quantitative autoradiography. Galanin receptors predominated in layers I and V of medial and lateral frontal cortex with a low regional index of occupancy by endogenous galanin. These receptors might be of functional relevance since the guanylnucleotide Gpp(NH)p inhibited [125I]galanin specific binding in each labeled region in the frontal lobe. Nevertheless, the striking areal difference of expression of this effect within the medial frontal cortex suggests that [125I]galanin binding sites might be coupled to one or more types of G-proteins related to the functionally distinct cortical subareas.
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