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  • Title: Molecular design of artificial hydrolytic nucleases and ribonucleases.
    Author: Komiyama M, Inokawa T, Shiiba T, Takeda N, Yoshinari K, Yashiro M.
    Journal: Nucleic Acids Symp Ser; 1993; (29):197-8. PubMed ID: 8247767.
    Abstract:
    Artificial nucleases and ribonucleases, which selectively hydrolyze the specific phosphodiester linkages in DNAs and RNAs, are prepared by the attachment of organic and inorganic catalysts to DNA oligomers as sequence-recognizing moieties. A hybrid of ethylenediamine and a 19-mer DNA selectively hydrolyzes tRNA(Phe) at the 3'-side of C63. Site-selective hydrolysis of DNAs has been accomplished by the lanthanide complexes bound to DNA oligomers. No concurrent oxidative cleavage of the ribose or the deoxyribose takes place.
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