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  • Title: Dialkylformamidine protected deoxyadenosine phosphoramidites in oligonucleotide synthesis.
    Author: Andrus A, Theisen PD, McCollum C.
    Journal: Nucleic Acids Symp Ser; 1993; (29):5-6. PubMed ID: 8247790.
    Abstract:
    A series of dialkylformamidine protected deoxyadenosine phosphoramidites were prepared for automated, solid-support DNA synthesis. The set of Abz, Gdmf, Cbz, T phosphoramidites gave high purity and high yield oligonucleotides, with rapid and complete deprotection at 65 degrees C in one hour. Different times and temperatures of exposure to concentrated ammonium hydroxide were examined to establish the optimum conditions for deprotection of oligonucleotides.
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