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  • Title: Relationship between pharmacological properties and clinical efficacy of ruminant anthelmintics.
    Author: Lanusse CE, Prichard RK.
    Journal: Vet Parasitol; 1993 Sep; 49(2-4):123-58. PubMed ID: 8249240.
    Abstract:
    The purpose of this review article is to establish a relationship between pharmacological properties and clinical efficacy of the most widely used broad-spectrum veterinary anthelmintics. The impact of drug pharmacokinetics/pharmacodynamics on anthelmintic efficacy and resistance is discussed. We review the clinical pharmacokinetics of the currently available anthelmintics used in livestock-imidazothiazoles, tetrahydropyrimidines, benzimidazoles/pro-benzimidazoles, salicylanilides (closantel) and avermectin-type compounds. Understanding the pharmacokinetic and metabolic behaviour of broad-spectrum anthelmintics in the host, and factors modulating that behaviour, is highly important for maximizing anthelmintic utility and efficacy.
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