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  • Title: [Protective effects of 3, 6-dimethamidodibenzopyriodinium citrate on myocardial injury induced by ischemia and reperfusion in rats].
    Author: Deng XL, Qiu PL, Liu JT, Chen SY.
    Journal: Zhongguo Yao Li Xue Bao; 1993 Jul; 14(4):367-9. PubMed ID: 8249638.
    Abstract:
    3, 6-Dimethamidodibenzopyriodonium citrate (I-65) 0.5 and 1 mg.kg-1 pretreatment reduced the size of myocardial infarct after ischemia for 40 min and reperfusion for 120 min. I-65 0.5 mg.kg-1 decreased myocardial creatine kinase, lactate dehydrogenase release, and Ca2+ accumulation after ischemia for 40 min and reperfusion for 120 min. The results show that I-65 prevents cardiac ischemia and reperfusion injury and the effect is considered to be related to inhibition of myocardial Ca2+ accumulation.
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