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  • Title: Parvalbumin-immunoreactive cortical neurons in Creutzfeldt-Jakob disease.
    Author: Ferrer I, Casas R, Rivera R.
    Journal: Ann Neurol; 1993 Dec; 34(6):864-6. PubMed ID: 8250537.
    Abstract:
    Massive abnormalities of parvalbumin-immunoreactive cortical neurons were observed in the cerebral biopsy samples of 3 patients with Creutzfeldt-Jakob disease. Immunoreactive cells had reduced and short, often fragmented, dendrites, and large numbers of dendritic varicosities were observed. Since parvalbumin-immunoreactive neurons are the most important inhibitory cells in the cerebral cortex, the damage to these neurons may account, in part, for the impaired cortical function, and may play a role in the appearance of myoclonus and electroencephalographic patterns in patients with Creutzfeldt-Jakob disease.
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