These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Cerebellar astrocytes specifically support the survival of Purkinje cells in culture.
    Author: Yuzaki M, Mikoshiba K, Kagawa Y.
    Journal: Biochem Biophys Res Commun; 1993 Nov 30; 197(1):123-9. PubMed ID: 8250916.
    Abstract:
    As a first step toward identifying the factor(s) that is/are produced by astrocytes and support(s) the survival of cerebellar Purkinje cells in dissociated culture, we compared the effect of astrocytes of cerebellar, hippocampal, and cerebral origin. A feeder coverslip of cerebellar astrocytes, which did not have cell-to-cell contact to neuronal culture, increased the percentage of Purkinje cells to about 8-9 fold with no change in the percentage of astrocytes. On the other hand, astrocytes of hippocampal or cerebral origin did not increase the percentage of Purkinje cells at low plating density, whereas they increased the number of astrocytes in neuronal culture. These results indicate that the factor(s), tentatively named as Purkinje-cell survival factor was/were specifically produced by cerebellar astrocytes and affected directly on Purkinje cells.
    [Abstract] [Full Text] [Related] [New Search]