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  • Title: Inhibition of dihydrofolate reductase by mofebutazon.
    Author: Strehl E, Schneider I, Elstner EF.
    Journal: Z Naturforsch C J Biosci; 1993; 48(9-10):815-7. PubMed ID: 8251039.
    Abstract:
    Mofebutazon, in contrast to phenylbutazon, inhibits dihydrofolate reductase in a concentration-dependent manner. An apparent Ki for mofebutazon and dihydrofolate reductase in the presence of NADPH as electron donor and dihydrofolate as electron acceptor of approximately 0.2 mM was calculated.
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