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  • Title: [Prophylactic and therapeutic effect of jiawei zhigancao tang injection on experimental arrhythmia in rats].
    Author: Cui ZQ, Zhang HR, Lin XZ.
    Journal: Zhongguo Zhong Xi Yi Jie He Za Zhi; 1993 Jul; 13(7):423-5, 389-90. PubMed ID: 8251728.
    Abstract:
    The antiarrhythmic effect of Jiawei Zhigancao Tang injection (JZTI) was studied in experimental arrhythmia induced by aconitine or by CaCl2 in anesthetized rats. The prophylactic dose of JZTI (5g/kg, i.v.) reduced the incidence rate of premature ventricular complexes, ventricular tachycardia (P < 0.01), delayed the onset time of arrhythmia induced by CaCl2 (P < 0.01), and the recovery time of sinus rhythm occurred earlier than that of control group (P < 0.01). The therapeutic dose of JZTI (10g/kg, i.v.) raised the rate of aconitine-induced arrhythmia to sinus rhythm conversion (P < 0.05). The results showed that JZTI could significantly antagonize arrhythmia induced by aconitine or by Cacl2 in rats.
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