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  • Title: Photodynamic elimination of clonogenic Ph+ chronic myeloid leukemia cells.
    Author: Keating A, Jamieson C, Hornby A, Wang XH, Levy J.
    Journal: Leuk Lymphoma; 1993; 11 Suppl 1():265-9. PubMed ID: 8251908.
    Abstract:
    Benzoporphyrin derivative (BPD) and light is a potent photosensitizer. We investigated this modality as a means to selectively eliminate clonogenic Ph(+) chronic myeloid leukemia (CML) cells. BPD at 10 ng/ml and 10.8 J/cm2 broad spectrum light eliminates from 5 to 6 logs of Ph(+) EM-2 cells. Long-term marrow culture studies of treated mixtures of normal and CML cells indicate that multipotent progenitor cell viability is retained while cells transcribing BCR-ABL are not detected. We conclude that BPD and light may offer a means of providing CML autografts potentially free of Ph(+) clonogenic cells.
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