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  • Title: A comparative burn wound model in the New Yorkshire pig for the histopathological evaluation of local therapeutic regimens: silver sulfadiazine cream as a standard.
    Author: Hoekstra MJ, Hupkens P, Dutrieux RP, Bosch MM, Brans TA, Kreis RW.
    Journal: Br J Plast Surg; 1993 Oct; 46(7):585-9. PubMed ID: 8252267.
    Abstract:
    A standard burn wound model was developed in the pig to enable evaluation of histopathological parameters of wound healing under different circumstances. Wounds on one flank were treated with silver sulfadiazine 1% cream (SSD, Flammazine-Duphar), which is a standard treatment. On identical places of the contralateral side different topical agents were applied. From the SSD treated burns a typical histopathologic picture of wound healing under SSD could be derived: SSD has the potential to preserve viable dermal tissue, epidermal regeneration is rather slow and irritated, while the formation of granulation tissue is pronounced, with an abundance of myofibroblasts.
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