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  • Title: Generalized melanosis with malignant melanoma metastasizing to skin--a pathological study with S-100 protein and HMB-45.
    Author: Péc J, Plank L, Mináriková E, Palencárová E, Rollová Y, Lazárová Z, Auxtová S, Lauko L.
    Journal: Clin Exp Dermatol; 1993 Sep; 18(5):454-7. PubMed ID: 8252770.
    Abstract:
    A patient with primary malignant melanoma localized to the right gluteal region is described. Four years later and after intercurrent influenza, disseminated metastases of malignant melanoma to the skin occurred. After a further 6 months melanodermia developed and lasted until the death of the patient (6 months later). Autopsy revealed melanosis of the visceral organs. Histology taken from internal organs using S-100 protein and HMB-45 melanoma methods confirmed metastases of malignant melanoma to the skin, oral cavity, palatal tonsils, nasal and nasopharyngeal mucosae, lungs, myocardium and brain. The authors discuss the mechanism of melanosis--a rare sign in patients with metastasizing malignant melanoma.
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