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  • Title: Pachyonychia congenita with late onset of nail dystrophy--a new clinical entity?
    Author: Iraci S, Bianchi L, Gatti S, Carrozzo AM, Bettini D, Nini G.
    Journal: Clin Exp Dermatol; 1993 Sep; 18(5):478-80. PubMed ID: 8252777.
    Abstract:
    Pachyonychia congenita syndrome (PCS) is a genetic disease with an autosomal dominant mode of transmission in which the main sign, pachyonychia, usually arises at birth or in childhood together with other disorders of keratinization. A 28-year-old woman developed subungual hyperkeratosis of all toe-nails and thumb-nails associated with pain on pressure and walking. She had a scrotal tongue with leucokeratotic areas, blister formation, plantar hyperkeratosis, palmoplantar hyperhidrosis and dental cavities since childhood. The present case, interpreted as PCS of late onset, could be a clinical variant of the Jadassohn-Lewandowsky syndrome with the late onset of pachyonychia or else an additional form of PCS due to the expression of a new and different allele.
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