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  • Title: Nitric oxide modulates Ca2+ channel currents in rat sympathetic neurons.
    Author: Chen C, Schofield GG.
    Journal: Eur J Pharmacol; 1993 Oct 12; 243(1):83-6. PubMed ID: 8253128.
    Abstract:
    The effects of nitric oxide on the Ca2+ channel currents of adult rat superior cervical ganglion neurons were investigated using the whole-cell patch-clamp technique. Nitric oxide-containing compounds sodium nitroprusside and S-nitroso-N-acetyl-penicillamine increased the amplitude of Ca2+ currents by intracellular application. In addition, both sodium nitroprusside and S-nitroso-N-acetylpenicillamine reduced norepinephrine-induced inhibition of Ca2+ currents. The results suggest that nitric oxide might be involved in the modulation of Ca(2+)-dependent neurotransmission in sympathetic neurons.
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