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  • Title: Electrophoretically defined myosin heavy chain patterns of single human muscle spindles.
    Author: Pedrosa-Domellöf F, Gohlsch B, Thornell LE, Pette D.
    Journal: FEBS Lett; 1993 Dec 06; 335(2):239-42. PubMed ID: 8253204.
    Abstract:
    At least four myosin heavy chain (MHC) isoforms were separated by SDS-PAGE in extracts of intrafusal fibers isolated by microdissection from human lumbrical muscles. The fastest migrating MHC represents a slow isoform. The slowest migrating MHC was identified as the embryonic MHCemb. A faint band, moving slightly faster than MHCemb, most likely represents a neonatal/fetal MHC isoform. A prominent band, moving between the latter and the slow isoform is suggested to represent a hitherto unidentified, spindle-specific MHC isoform, MHCif.
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