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  • Title: Alpha-chain disease with localized plasmacytoma of the intestine. Immunoperoxidase study.
    Author: Skinner JM, Manousos ON, Economidou J, Nicolaou A, Merikas G.
    Journal: Clin Exp Immunol; 1976 Jul; 25(1):112-6. PubMed ID: 825335.
    Abstract:
    An ileocaecal tumour in a patient with alpha-chain disease in remission was studied immunohistochemically by a quantitive immunoperoxidase method. The tumour which was histologically shown to be a plasmacytoma consisted of 68% alpha cells and 15% lambda cells; no kappa cells were found. Away from the tumour the pattern of immunoglobulin-producing cells was normal. It is concluded that the abnormal cell causing alpha-chain disease remains inactive and that the patient developed a plasmacytoma from a different cell clone.
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