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  • Title: Plasma renin activity and renal sodium and water excretion following infusion of arachidonic acid in rats.
    Author: Weber P, Holzgreve H, Stephan R, Herbst R.
    Journal: Eur J Pharmacol; 1975 Dec; 34(2):299-304. PubMed ID: 825378.
    Abstract:
    Plasma renin activity (PRA) and urinary sodium and water excretion were measured following infusion of the prostaglandin (PG) precursor arachidonic acid (C20:4) in normal hydrated rats (saline i.v.:0.5 ml/hr/100 g body weight) and in rats with moderate volume expansion (saline i.v.:1.5 ml/hr/100 g body weight). Nonhypotensive doses of C20:4(40-70 mu/min/100 g b.w.) increased PRA in both normal and volume-expanded rats (p less than 0.05, and p less than 0.025, respectively). In volume-expanded rats, C20:4 was followed by reduced lrine volume (p less than 0.01) and sodium excretion (p less than 0.001) in comparison to volume-expanded control rats, whereas in normal hydrated rats these parameters remained unchanged after C20:4. The present results indicate that the C20:4-stimulated PG-synthetase system can increase PRA independently of the extracellular fluid volume. Furthermore, these results suggest a complex interrelationship between PG-synthetase action, activation of the renal renin-angiotensin system and urinary water and sodium excretion.
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