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  • Title: Effects of calcium channel entry blockers on cocaine and amphetamine-induced motor activities and toxicities.
    Author: Ansah TA, Wade LH, Shockley DC.
    Journal: Life Sci; 1993; 53(26):1947-56. PubMed ID: 8255157.
    Abstract:
    The effects of calcium channel entry blockers on cocaine and amphetamine-induced behavioral responses were investigated. Cocaine and amphetamine produced dose-dependent increases in locomotor activity and stereotyped behavior with a maximum response at 40 and 1.2 mg/kg, respectively. The 1,4-dihydropyridine nimodipine and the benzothiazepine diltiazem were more effective in inhibiting cocaine (20 mg/kg)-induced responses than amphetamine (0.6 mg/kg)-induced responses. At doses of cocaine and amphetamine that caused seizures and death, nimodipine, nitrendipine and diltiazem did not offer any protection; rather, they potentiated the toxicities produced by these psychomotor stimulants.
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