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  • Title: IgA, IgG, and anti-Pasteurella multocida antibody levels in bursectomized and/or cyclophosphamide-treated turkeys after CU vaccination.
    Author: Schlink GT, Olson LD, Saif YM, Jackwood DJ.
    Journal: Avian Dis; 1993; 37(3):668-72. PubMed ID: 8257356.
    Abstract:
    In bursectomized, cyclophosphamide-treated, and bursectomized/cyclophosphamide-treated turkeys, IgA, IgG, and anti-Pasteurella multocida were determined before and after vaccination with the Clemson University (CU) strain of P. multocida. Before vaccination, the average total serum level of IgA was significantly (P < 0.05) lower in bursectomized and bursectomized/cyclophosphamide-treated turkeys than in untreated controls, and the average serum levels of anti-P. multocida were significantly (P < 0.05) lower in bursectomized, cyclophosphamide-treated, and bursectomized/cyclophosphamide-treated turkeys than in untreated controls. After vaccination, average serum IgA levels were still significantly (P < 0.05) lower in all treated groups of turkeys than in the untreated controls. Also after vaccination, total IgG increased significantly (P < 0.05) only in the bursectomized turkeys, and serum anti-P. multocida antibody levels increased significantly (P < 0.05) in cyclophosphamide-treated, bursectomized/cyclophosphamide-treated, and untreated turkeys. After challenge with virulent P. multocida, survivability was significantly (P < 0.05) lower in the three treated groups of turkeys than in the untreated groups.
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