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  • Title: Preliminary Results of trials of chemotherapy in advanced ovarian carcinoma.
    Author: Young RC, Chabner BA, Hubbard SP, Canellos GP, DeVita VT.
    Journal: Natl Cancer Inst Monogr; 1975 Oct; 42():145-8. PubMed ID: 825777.
    Abstract:
    A search for improved forms of systemic chemotherapy in advanced ovarian carcinoma has resulted in two prospective trials at the Medicine Branch National Cancer Institute. The first trial compared high-dose, split-course intravenous cyclophosphamide with conventional treatment with an oral alkylating agent, melphalan [also called L-phenylalanine mustard (PAM)]. While both regimens were essentially equal in therapeutic efficacy, the former was considerably more toxic and the latter was therefore preferred. The second trial employed a 4-drug combination (5-fluorouracil, methotrexate, cyclophosphamide, and hexamethylmelamine); the results indicated a higher overall response rate (85%) and a higher complete remission rate (31%) with the combination therapy than with the PAM therapy, although the study is short and the observations are preliminary.
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