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  • Title: Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice.
    Author: Katz J, Benoist C, Mathis D.
    Journal: Eur J Immunol; 1993 Dec; 23(12):3358-60. PubMed ID: 8258349.
    Abstract:
    An early step in the development of autoimmune diabetes is lymphocyte infiltration into the islets of Langerhans of the pancreas, or insulitis. The infiltrate contains both CD4+ and CD8+ T cells and both are required for progression to diabetes in non-obese diabetic (NOD) mice. It has been thought that the CD4+ lymphocytes are the initiators of the disease, the islet invaders, while CD8+ cells are the effectors, the islet destroyers. We question this interpretation because NOD mice lacking MHC class I molecules, hence CD8+ T cells, do not display even insulitis when expected.
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