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  • Title: An assessment of the success of meperidine and promethazine sedation in medically compromised children.
    Author: Haney KL, McWhorter AG, Seale NS.
    Journal: ASDC J Dent Child; 1993; 60(4-5):288-94. PubMed ID: 8258571.
    Abstract:
    A retrospective study evaluated the success of orally administered meperidine (1.0 mg/lb) and promethazine (0.5 mg/lb) combined with N20:02, and determined predictors of success in a medically, physically and/or mentally compromised population. Behavior of 143 uncooperative patients (mean age 6.4 years) was evaluated during 282 sedations. A simplified Success Index rated outcome: 1-failure, 2-moderately successful; 3-highly successful. Variables were examined for effect on outcome of sedation: physical and/or neurologic component of medical diagnosis; previous hospital experience; medication category. Children taking medications with CNS actions were significantly less likely to have either moderately successful (p = .008) or highly successful appointments (p = .002). Children with a neurologic component to their medical diagnosis were significantly less likely to have a highly successful appointment (p = .001). Oral sedation was effective for this population (77 percent were successful) and certain characteristics of the patient's condition can predict success.
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