These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Regulation of anti-Sm autoantibodies by the immunoglobulin heavy chain locus.
    Author: Halpern MD, Craven SY, Cohen PL, Eisenberg RA.
    Journal: J Immunol; 1993 Dec 15; 151(12):7268-72. PubMed ID: 8258724.
    Abstract:
    Anti-Sm antibodies are specific markers for systemic lupus erythematosus in MRL mice and in humans. The prevalence of anti-Sm positivity in inbred MRL/Mp-lpr/lpr(MRL/lpr) mice is consistently about 25% at 5 mo of age, when the disease is at its peak. The control of the development of anti-Sm in individual MRL/lpr mice has been shown to be the result of stochastic factors, and previous research has indicated that the immunoglobulin heavy chain (IgH) b allotype may be more amenable to the production of anti-Sm. We have now further investigated the influence of the IgH genetic locus on the production of anti-Sm and other autoantibodies in an allotype congenic MRL strain, the MRL/Mp-Ipr/Ipr-IgHb (MRL/lpr-IgHb). Strikingly, 78% of MRL/lpr-IgHb mice produced anti-Sm, compared with 27% of contemporaneous MRL/lpr (IgHj) mice. Of those mice that were positive for anti-Sm, the MRL/lpr-IgHb strain produced significantly higher levels of anti-Sm than did the anti-Sm positive MRL/lpr mice. No differences were observed between the conventional MRL/lpr and the MRL/lpr-IgHb levels of antichromatin, anti-ssDNA, antiribosomal P, or anti-Su. In addition, kidney function, which was assessed by measuring serum urea nitrogen levels, was similar in the two strains. These results support the notion that the control of anti-Sm production in MRL/lpr mice operates through the IgH locus.
    [Abstract] [Full Text] [Related] [New Search]