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  • Title: Progressive Schnyder's corneal dystrophy.
    Author: Ingraham HJ, Perry HD, Donnenfeld ED, Donaldson DD.
    Journal: Ophthalmology; 1993 Dec; 100(12):1824-7. PubMed ID: 8259281.
    Abstract:
    BACKGROUND: Schnyder's crystalline dystrophy is a central anterior bilateral corneal dystrophy characterized by the deposition of crystals composed of cholesterol and other lipids. This condition classically is described as nonprogressive after childhood, but a series of recent studies following patients over time has challenged this teaching. PATIENTS: The authors present a family pedigree including a patient first reported in 1954 and followed for 25 years with dramatic progression of the corneal condition in a dense, discoid pattern of crystals. Best-corrected visual acuity decreased from 20/30 to 20/80 in both eyes. This patient now has three children, all with typical corneal involvement. RESULTS: Ocular pathologic examination performed on corneal biopsies submitted for light and electron microscopy demonstrated cholesterol deposition consistent with a diagnosis of Schnyder's. CONCLUSION: Schnyder's corneal dystrophy may progress significantly over time. The characterization of this condition as stationary may need to be reconsidered.
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