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  • Title: Elements of the yeast pheromone response pathway required for filamentous growth of diploids.
    Author: Liu H, Styles CA, Fink GR.
    Journal: Science; 1993 Dec 10; 262(5140):1741-4. PubMed ID: 8259520.
    Abstract:
    Transmission of an external signal from receptors to downstream targets is often mediated by a conserved set of protein kinases that act in sequence (a kinase cascade). In haploid strains of Saccharomyces cerevisiae, a signal initiated by peptide pheromones is transmitted through this kinase cascade to a transcription factor STE12, which is required for the expression of many mating-specific genes. Here it was shown that in diploids some of the same kinases and STE12 are required for filamentous growth, but the pheromone receptors and guanosine triphosphate-binding protein are not required for filament formation. Thus, a similar kinase cascade is activated by different signals in haploids and diploids and mediates different developmental outcomes in the two cell types.
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