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  • Title: The use of sumatriptan in the treatment of migraine.
    Author: Gross M.
    Journal: Br J Clin Pract; 1993; 47(4):205-7. PubMed ID: 8260340.
    Abstract:
    Sumatriptan is a selective agonist of 5-hydroxytryptamine receptors, recommended for the acute treatment of migraine. The 5-HT1 receptor subtype is found in the cranial vasculature of many species including humans, and causes vasoconstriction of these vessels. Sumatriptan as a highly potent 5-HT1 agonist selectively constricts large intracranial blood vessels and also blocks neurogenic inflammation. Those treating patients with severe or inconveniently timed attacks will find sumatriptan the drug of choice.
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