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  • Title: The presence of secretory component-free human colostral IgA in early colostrum.
    Author: Petryniak J, Janusz M, Bialkowska H, Dutkiewicz K, Boratyński J, Lisowski J.
    Journal: Arch Immunol Ther Exp (Warsz); 1976; 24(5):659-70. PubMed ID: 826232.
    Abstract:
    Human secretory IgA was prepared from colostrum. Different elution diagrams from CM-cellulose were obtained depending on the time of collection of colostrum. In case of early colostrum, collected within 6 hours post partum, two IgA fractions were obtained after chromatography on CM-cellulose. Both fractions have different molecular weights and different amino acid compositions. The results obtained suggest that the first fraction is a dimer of IgA monomers containing J chain with a molecular weight of 330,000 whereas the second fraction having the molecular weight 395,000 daltons is composed of IgA dimer, J chain and SC. When colostrum collected 48 or more hours was used as a source of IgA, only the second IgA fraction was obtained. The problem of SC-free IgA immunoglobulins is discussed.
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