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  • Title: Inhibition of malaria parasite development in mosquitoes by anti-mosquito-midgut antibodies.
    Author: Lal AA, Schriefer ME, Sacci JB, Goldman IF, Louis-Wileman V, Collins WE, Azad AF.
    Journal: Infect Immun; 1994 Jan; 62(1):316-8. PubMed ID: 8262645.
    Abstract:
    The mosquito midgut plays a central role in the development and subsequent transmission of malaria parasites. Using a rodent malaria parasite, Plasmodium berghei, and the mosquito vector Anopheles stephensi, we investigated the effect of anti-mosquito-midgut antibodies on the development of malaria parasites in the mosquito. In agreement with previous studies, we found that mosquitoes that ingested antimidgut antibodies along with infectious parasites had significantly fewer oocysts than mosquitoes in the control group. We also found that the antimidgut antibodies inhibit the development and/or translocation of the sporozoites. Together, these observations open an avenue for research toward the development of a vector-based malaria parasite transmission-blocking vaccine.
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