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  • Title: Tardive dyskinesia, lipid peroxidation, and sustained amelioration with vitamin E treatment.
    Author: Peet M, Laugharne J, Rangarajan N, Reynolds GP.
    Journal: Int Clin Psychopharmacol; 1993; 8(3):151-3. PubMed ID: 8263312.
    Abstract:
    Plasma levels of thiobarbituric acid reactive substances (TBARS) were measured as an indicator of lipid peroxidation, in 14 patients suffering from tardive dyskinesia (TD). There was a highly significant positive correlation between plasma TBARS (both basal and iron stimulated) and severity of TD. Patients were then treated for 1 month with the free radical scavenger vitamin E (1200 i.u. daily). Following vitamin E treatment, there was a clinically and statistically significant amelioration of TD, and this improvement was maintained at follow-up 7-13 months later. There was no consistent or significant change in plasma TBARS levels related to treatment with vitamin E.
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