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  • Title: [Alpha-chain disease presenting as malabsorption syndrome with exudative enteropathy (author's transl)].
    Author: Roth S, Havemann K, Kalbfleisch H, Menge H, Riecken EO, Sodomann CP, Martini GA.
    Journal: Dtsch Med Wochenschr; 1976 Dec 10; 101(50):1823-8. PubMed ID: 826383.
    Abstract:
    A 30-year-old Turk was admitted with signs of exudative enteropathy together with malabsorption. There was no improvement on a gluten-free diet. Immunological investigations demonstrated atypical IgA-immunoglobulin in the serum which did not precipitate with antisera against L-chains. Peroral ileal biopsy and surgical biopsy material showed a diffuse proliferation of plasma cells in an altered ileal mucosa and in the mesenteric lymph nodes. Skeletal X-rays showed no osteolysis and the bone marrow showed no evidence for multiple myeloma. Treatment with melphalan and steroids resulted in a three year remission. In the terminal stage an intra-abdominal malignant lymphoma developed.
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