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  • Title: Novel potential mechanism-based inhibitors of human leukocyte elastase and cathepsin G: derivatives of isothiazolidin-3-one.
    Author: Groutas WC, Chong LS, Venkataraman R.
    Journal: Biochem Biophys Res Commun; 1993 Dec 15; 197(2):730-9. PubMed ID: 8267609.
    Abstract:
    A series of heterocyclic compounds designed to function as mechanism-based inhibitors of human leukocyte elastase and cathepsin G has been synthesized and their inhibitory activity was investigated. These isothiazolidin-3-one derivatives were found to be effective inhibitors of cathepsin G.
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