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  • Title: PEC-60, a novel regulatory peptide reduces cyclic AMP formation in rat caudate nucleus.
    Author: Laasik J, Sillard R.
    Journal: Biochem Biophys Res Commun; 1993 Dec 15; 197(2):849-52. PubMed ID: 8267623.
    Abstract:
    PEC-60, a sixty-residue novel regulatory peptide with N-terminal glutamic acid and C-terminal cysteine is abundant in intestinal tissue. PEC-60-like immunoreactivity is found in catecholamine neurons and intracerebroventricular injections of PEC-60 reduce dopamine utilization within the caudate nucleus indicating a possible role of this peptide in the central nervous system. We have investigated the effect of PEC-60 on cAMP formation in membrane preparations from rat caudate nucleus. We have found that PEC-60 significantly and dose-dependently reduces basal and forskolin stimulated cAMP production. The results demonstrate for the first time the interaction of PEC-60 with specific binding sites that regulate adenylate cyclase in inhibitory fashion in rat caudate nucleus.
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