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  • Title: [Conjugation of classic Bowman-Birk soy inhibitor with a copolymer of ethylene oxide and propylene oxide].
    Author: Larionova NI, Gladysheva IP, Topchieva IN, Kazanskaia NF.
    Journal: Biokhimiia; 1993 Oct; 58(10):1658-64. PubMed ID: 8268307.
    Abstract:
    A classical soybean inhibitor of the Bowman-Birk type (BBI) with a copolymer of ethylene oxide and propylene oxide (PE) has been synthesized. The BBI-PE conjugate contain five covalently bound polymeric chains per one protein molecule and retains its capacity to inhibit trypsin (Ki = 10(-10) M), alpha-chymotrypsin (Ki = 7 x 10(-8) M) and human granulocyte elastase (Ki = 3 x 10(-8) M). The preservation of the antiproteinase activity in the antichymotrypsin center creates a prerequisite for the manifestation of the anticarcinogenic effect of the inhibitor.
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