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  • Title: The zinc-immunodeficiency relationship in old patients.
    Author: Bădulici S, Chirilă M, Cojocaru M, Buzică C, Voicu G.
    Journal: Rom J Intern Med; 1993; 31(2):123-30. PubMed ID: 8268830.
    Abstract:
    The influence of oral zinc sulphate therapy on the humoral immunity was investigated by dosages of serum immunoglobulins (Ig) and of plasma zinc levels in 12 patients with a mean age of 70 years, in comparison with other 11 patients treated with placebo and with a control group of 50 apparently healthy subjects. The results of this double-blind study demonstrated the zinc effect on the immunoregulation, as the Ig levels, and particularly those of the IgG class, initially high, were lowered in a statistically significant proportion. It is assumed that further clinical trials with various zinc concentrations could bring more information on this trace element participation in the humoral immunoregulation.
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