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  • Title: [Therapy with fibrates and vitamin D metabolism].
    Author: Wilczek H, Sobra J, Ceska R, Justová V, Procházková R, Kvasilová M, Jůzová Z.
    Journal: Cas Lek Cesk; 1993 Oct 25; 132(20):630-2. PubMed ID: 8269466.
    Abstract:
    The authors investigated in 29 patients with familial hyperlipoproteinaemia the effect of fibrate treatment (Duolip forte, Merckle, and Lipanthyl, Richter) on vitamin D metabolism. In 10 patients treated for 6 months with daily oral doses of 500 mg Duolip forte they did not prove changes of plasma levels of 25-hydroxyvitamin D, however, they recorded a rise of the 1,25-dihydroxyvitamin D3 plasma level. In 19 patients who were given for 6 months 300 mg Lipanthyl per day by the oral route they proved a significant decline of the 25-hydroxyvitamin D plasma levels and a rise of 1,25-dihydroxyvitamin D3 plasma levels. The authors maintain that fibrates influence plasma concentrations of vitamin D metabolites either directly or indirectly by reducing cholesterol plasma levels.
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