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  • Title: The topical application of verapamil and nifedipine lowers intraocular pressure in conscious rabbits.
    Author: Segarra J, Santafé J, Garrido M, Martínez de Ibarreta MJ.
    Journal: Gen Pharmacol; 1993 Sep; 24(5):1163-71. PubMed ID: 8270176.
    Abstract:
    1. The time-course of the ocular effects of topical verapamil and nifedipine as well as the dose-response relationship, were studied in conscious, normotensive rabbits. 2. Both drugs caused a dose-dependent fall of intraocular pressure, which lasted 4 hr or more. 3. Log dose-response curves of both drugs show a similar peak response, but the potency of verapamil was greater that of nifedipine. 4. A fall in the intraocular pressure in the untreated eye was also observed. 5. Verapamil and nifedipine induced a reduction of the tonographic outflow facility in the treated eye.
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