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  • Title: Antibody to hepatitis-C virus in multi-transfused thalassaemics--Indian experience.
    Author: Agarwal MB, Malkan GH, Bhave AA, Vishwanathan C, Billa V, Dube SR, Bajan K, Rajadhyaksha GC, Shah SH.
    Journal: J Assoc Physicians India; 1993 Apr; 41(4):195-7. PubMed ID: 8270554.
    Abstract:
    Twelve out of 72 (16.7%) multi-transfused patients with thalassemia major (age range: 7-22 years) were found to be positive for antibody to hepatitis-C virus (anti-HCV). Nine (75%) of these 12 cases were positive for hepatitis B core antibody (anti-HBc) and/or hepatitis B surface antibody (anti-HBs). Out of the remaining 60 patients (83.3%), 27 patients (45%) were positive for anti-HBc and/or anti-HBs, while six (10%) were HBsAg positive Anti-HCV positive patients had significant higher levels of liver enzymes than those who were negative (p < 0.01). S. Ferritin was also significantly higher in those with seropositivity for anti-HCV than those who were negative (p < 0.01). It is concluded that HCV (besides HBV) is a major problem in multi-transfused thalassemia major patients and routine pre-transfusion screening of blood for anti-HCV must be introduced in the blood banks.
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