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  • Title: A randomized controlled trial of solcoseryl and duoderm in chronic sickle-cell ulcers.
    Author: La Grenade L, Thomas PW, Serjeant GR.
    Journal: West Indian Med J; 1993 Sep; 42(3):121-3. PubMed ID: 8273321.
    Abstract:
    A randomized controlled trial of Solcoseryl, DuoDerm and conventional conservative therapy with Eusol has been performed in 32 patients with homozygous sickle-cell (SS) disease. After 12 weeks' baseline observation, patients were randomized to one of three therapies and monitored for a further 12 weeks. Of 44 ulcerated legs, 20 received control treatment, 12 Solcoseryl and 12 DuoDerm. DuoDerm was generally unacceptable, and two-thirds of the patients defaulted from this treatment. Solcoseryl increased ulcer healing compared to the controls but the difference was not significant. Solcoseryl was well tolerated and may have a role in the treatment of chronic leg ulcers of sickle-cell disease.
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