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  • Title: Potential antiinflammatory agents N-carboxyalkyl derivatives of barbituric acid.
    Author: Sladowska H.
    Journal: Farmaco Sci; 1976 Oct; 31(10):714-30. PubMed ID: 827452.
    Abstract:
    The synthesis and investigation of the structure of N-carboxyalkyl derivatives of barbituric acids are described. In the solid state 3-carboxymethyl-1-phenylbarbitone has the structure of a hemiketal, the corresponding 1-cyclohexyl derivative was not cyclized to the hemiketal and 3-carboxymethyl-5-ethyl-1-phenylbarbituric acid was a mixture of the cyclized and open structures. Some of the compounds were found to be very weak inhibitors of prostaglandin synthetase.
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